Uterine inversion - NYSORA

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Uterine inversion

Learning objectives

  • Description and four degrees of uterine inversion
  • Signs and symptoms of uterine inversion
  • Management of uterine version

Definition and mechanisms

  • Uterine inversion is a rare complication when the uterine fundus collapses into the endometrial cavity, turning the uterus partially or completely inside out
  • A life-threatening obstetric emergency as it can lead to severe blood loss, shock, and even maternal death
  • In extremely rare cases (5% of uterine inversions), fibroids or tumors cause uterine inversion
  • Four degrees of uterine inversion:
    • 1st degree (incomplete): the fundus is within the endometrial cavity
    • 2nd degree (complete): the fundus protrudes through the cervical os
    • 3rd degree (prolapsed): the fundus protrudes to or beyond the introitus
    • 4th degree (total): both the uterus and vagina are inverted and protrude outside the body
  • Time of occurrence:
    • Acute: within 24 hours of delivery
    • Subacute: more than 24 hours but less than four weeks postpartum
    • Chronic: ≥ 1 month postpartum
  • The incidence ranges from 1 in 3500 to 20,000 deliveries

Signs and symptoms

  • Postpartum bleeding
  • Abdominal pain
  • A smooth, round mass protruding from the cervix or vagina
  • Urinary retention
  • Hypotension
  • Hemodynamic shock
  • Bradycardia

Causes

  • Mismanagement of the third stage of labor such as:
    • Fundal pressure
    • Excess cord traction during the third stage of labor
  • Other natural causes can be:
    • Uterine weakness
    • Precipitate delivery
    • Short umbilical cord
  • It is more common in multiple gestations than in singleton pregnancies

Risk factors

  • Short umbilical cord
  • Rapid or prolonged labor and delivery
  • Use of uterine relaxants
  • Nulliparity
  • Fetal macrosomia
  • Retained placenta
  • Severe pre-eclampsia
  • Uterine atony
  • Placenta accreta spectrum
  • Uterine anomalies or tumors (leiomyoma)

Complications

Diagnosis

  • Clinical findings
  • Ultrasound examination shows an abnormal uterine fundal contour with a homogenous globular mass within the uterus

Management

Uterine inversion, uterotonic agents, placenta, Johnson maneuver, constriction ring, laparotomy, terbutaline, magnesium sulphate, sevoflurane, desflurane, isoflurane, oxytocin, carboprost, misoprostol

Suggested reading

  • Macones G. 2022. Peurperal uterine inversion. Up to date. 
  • Wendel MP, Shnaekel KL, Magann EF. Uterine Inversion: A Review of a Life-Threatening Obstetrical Emergency. Obstet Gynecol Surv. 2018;73(7):411-417.
  • Shepherd LJ, Shenassa H, Singh SS. Laparoscopic management of uterine inversion. J Minim Invasive Gynecol. 2010;17(2):255-257.

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