A breakthrough randomized controlled trial by Trocheris-Fumery et al. reveals that the early administration of norepinephrine during anesthesia induction significantly reduces postoperative complications in high-risk patients undergoing major abdominal surgery. Background Intraoperative hypotension, a common drop in blood pressure following the induction of anesthesia, has long been associated with adverse outcomes, including: Myocardial injury Acute kidney injury (AKI) Increased mortality risk Despite this, standard vasopressor regimens vary, and evidence comparing strategies for preventing such hypotension is limited. Study overview A research team at Amiens Hospital University in France conducted the EPON trial (Early Use of Norepinephrine), a single-center, randomized controlled study, to evaluate whether prophylactic norepinephrine infusion could better prevent postinduction hypotension and its associated complications compared to standard treatment with reactive ephedrine boluses. Key study details: Design: Prospective, randomized, open-label, single-center Patients: 500 adults aged >50 undergoing major abdominal surgery Groups: Norepinephrine group: Prophylactic continuous infusion (0.48 mg/h) Ephedrine group: Reactive boluses (3 mg each, max 30 mg) How the intervention works Core findings Reduction in complications Primary endpoint: Medico-surgical complications within 30 days (Clavien–Dindo score ≥1) Ephedrine group: 58% Norepinephrine group: 44% Relative risk (RR): 0.58 [0.40–0.83]; P = 0.004 Pulmonary benefits Postoperative pulmonary complications (PPCs) at 48 hours: Ephedrine: 31% Norepinephrine: 17% Hemodynamic stability Hypotensive episodes occurred in: 74% of ephedrine group Only 15% of the norepinephrine group Norepinephrine also resulted in: Higher mean arterial pressure (MAP) post-induction Lower intraoperative lactate levels (suggesting better organ perfusion) How norepinephrine works Norepinephrine is a potent α1- and β1-adrenergic agonist, leading to: Vasoconstriction (↑ blood pressure) Improved cardiac output Stable hemodynamics during anesthesia induction Unlike ephedrine, it avoids tachyphylaxis (diminished effect with repeated use) and is increasingly considered for first-line vasopressor use in anesthesia. Subgroup insights Norepinephrine was especially effective in reducing complications among: ASA III patients Men Patients without […]
Regional anesthesia is increasingly recognized as an essential component of pediatric anesthetic care. Its benefits are clear: reduced postoperative pain, decreased opioid consumption, and faster recovery, all of which improve outcomes and minimize adverse events. However, most anatomical knowledge underpinning pediatric regional anesthesia is extrapolated from adult studies. Neonates and infants are not simply “small adults”—their anatomy differs in ways that may significantly affect the accuracy and safety of nerve blocks. The superficial cervical plexus (SCP), formed by the anterior rami of C1–C4, provides sensory innervation to the anterolateral neck and areas of the head and shoulder. Its cutaneous branches (great auricular, lesser occipital, supraclavicular, and transverse cervical nerves) typically emerge at the midpoint of the posterior border of the sternocleidomastoid (SCM)—a landmark often called the “nerve point of the neck.” In adults, this nerve point is a reliable target for SCP blocks, widely applied for thyroidectomy, mastoidectomy, cleft excision, and cochlear implantation. Until now, little anatomical data existed for neonates, leaving clinicians to rely on adult-derived assumptions. This study by Prigge et al. aimed to define neonatal-specific anatomy of the SCP, providing evidence-based landmarks for safe and effective nerve blocks in the youngest patients. Study objective and methods The primary objective of this anatomical study was to precisely locate the superficial cervical plexus in neonates and establish standardized anatomical landmarks to guide SCP blocks. Design: Observational, cross-sectional anatomical study. Setting: Department of Anatomy, University of Pretoria, South Africa. Subjects: 22 embalmed neonatal cadavers (0–28 days old, normal birth weight, no congenital abnormalities). Dissection protocol: Supine positioning with contralateral head rotation to simulate patient positioning. Layered dissection of the cervical region to expose the SCP at its emergence from the posterior border of the SCM. Identification of cutaneous branches (great auricular, lesser occipital, supraclavicular, and transverse cervical nerves). Relation to […]
What’s new The 2025 DAS guideline, titled “Management of unanticipated difficult tracheal intubation in adults”, is a major update authored by Imran Ahmad et al. and published in the British Journal of Anaesthesia. Key features: 1,241 papers reviewed via systematic review, three‑round Delphi process over 3 years. 65 recommendations covering major domains: assessment, peroxygenation, human factors, post‑intubation care, and more. Maintains the linear algorithm of Plan A → Plan B → Plan C → Plan D (intubation → supraglottic airway → facemask ventilation → emergency front‐of‐neck airway). Emphasises maximising success (first pass, oxygenation) rather than only managing failures. Why this matters Unanticipated difficult airway situations remain a key source of perioperative morbidity and mortality; updated evidence means practice must evolve. Clinicians now have a modern, evidence‑based tool to guide management when intubation becomes challenging. The guideline synthesises technological advances (e.g., videolaryngoscopy, point‑of‑care ultrasound), human factors, and systems thinking into airway management. Highlighted domains and key changes 1. Pre‑intubation assessment & planning The guideline reinforces structured airway assessment AND creates a strategy for the physiologically difficult airway (e.g., shock, severe hypoxia, obesity). Planning includes preparation of equipment, team roles, backup plans, and the use of cognitive aids. 2. Peroxygenation and oxygenation strategies Continuous oxygen delivery throughout airway management is prioritised. Strategies such as high‑flow nasal oxygen, non‑invasive ventilation, and head‑up ramping are given emphasis. 3. First‑pass success and device strategy The document emphasises maximising first‑attempt intubation success using appropriate tools and techniques. Universal use of videolaryngoscopy is increasingly expected, and the guideline incorporates evidence for this. 4. Using the algorithm: Plan A to D Plan A: Tracheal intubation. Plan B: Supraglottic airway device ventilation. Plan C: Facemask ventilation. Plan D: Emergency front‑of‑neck airway (eFONA). The guideline reinforces the importance of rapid progression through plans if failure occurs, and clear criteria for when to move to the next plan. 5. Human factors, teamwork & training […]