Figure 1: Intravenous regional anesthesia: Injection of local anesthetic and placement of the tourniquet.
Indications: short operative procedures for the extremities; pain therapy (e.g., treatment of recurrent complexpain syndrome); treatment of hyperhidrosis
Local anesthetic: 12-15 mL of 2% lidocaine for upper extremities (or 30-40 mL of 0.5% lidocaine)
Relative contraindications: crush injuries; inability to access peripheral veins; infections (skin, cellulitis); compound fractures; convincing history of allergy to local anesthetics (LAs); severe peripheral vascular disease; atrioventricular shunts; severe hepatic insufficiency; disrupted integrity of venous system; sickle cell disease
Complexity level: Basic
Figure 2: Equipment for intravenous (IV) regional anesthesia consists of IV catheter, Esmarch, and local anesthetic.
Intravenous regional anesthesia (IVRA) was first described in 1908 by the German surgeon A.G. Bier, hence the procedure name Bier block. Originally, anesthesia was obtained by the intravenous injection of procaine in a previously exsanguinated vascular space, isolated from the rest of the circulation by two Esmarch bandages used as tourniquets. After initial enthusiasm, the technique fell into obscurity for >50 years. In 1963, Holmes reintroduced the Bier block with the novel use of lidocaine, describing a series of 30 patients in The Lancet. Today, intravenous regional anesthesia of the upper limb remains popular because it is reliable, cost effective, safe, and simple to administer. It is a widely accepted technique well suited for brief minor surgeries such as wrist or hand ganglionectomy, carpal tunnel release, Dupuytren contractures, reduction of fractures, and others. Since the duration of anesthesia depends on the length of time the tourniquet is inflated, there is no need to use long-acting or more toxic agents. Its application for longer surgical procedures is precluded by the discomfort caused by the tourniquet, typi- cally beginning within 30 to 45 minutes. Other disadvantages include incomplete muscle relaxation (where important) and lack of postoperative pain relief. With the implementation of a safety protocol and with meticulous attention to detail, concerns about local anesthetic (LA) toxicity should merely be a theoretical issue.
The only relevant anatomy is the location and distribution of peripheral veins in the extremity to be blocked. By preference, a vein as distal as possible is chosen. The antecubital fossa is an alternative only when more distal peripheral access is lacking.
Distribution of Anesthesia
Figure 3: A small gauge intravenous catheter is inserted in the peripheral vein and secured.
The entire extremity below the level of the tourniquet is anesthetized. Numerous radiographic, radioisotope, and neurophysiologic studies looked into the site of action of IVRA. However, the exact mechanism still remains the subject of debate and controversy. The likely mechanism is that the local anesthetic, via the vascular bed, reaches both peripheral nerves and nerve trunks (vasae nervorum), and nerve endings (valveless venules). Diffusion of local anesthetic into the surrounding tissues also plays a role. Ischemia and compression of the peripheral nerves at the level of the inflated cuff is probably another contributory component of the mechanism of IVRA. Again, anesthesia achieved by intravenous regional anesthesia is limited only by the inevitable pain due to tourniquet application; and, therefore, it is used typically for procedures lasting 30 to 45 minutes.
Equipment includes the following items (Figure 2):
Local anesthetic agent: lidocaine HCl (0.25-2%)
IV catheters (18- or 20-gauge)
500-mL or 1-L bag of IV solution (crystalloid)
Pneumatic tourniquet, ideally with a double cuff
One Esmarch bandage (about 150 cm in length, 10 cm in width)
Figure 4: A double well-padded tourniquet is placed on the upper arm. The arm is elevated to allow for passive exsanguinations.
Positioning and Preparation
The patient lies in the supine position with the vein selected for block placement readily accessible. Baseline vital signs are assessed; blood pressure, oxygen saturation, and ECG monitoring are applied. Intravenous access in the nonoperated extremity is obtained. Small doses of benzodiazepine for anxiolysis or small aliquots of opioids in case of discomfort, or both, may be administered. Adequate premedication will improve tourniquet tolerance and benzodiazepines can prevent the potential central nervous system signs of mild local anesthetic toxicity should the level of local anesthetic raise. An intact tourniquet system is essential for success and safety. Therefore, pneumatic cuffs always must be checked for air leaks before starting any IVRA procedure.
Figure 5: With the arm elevated, an Esmarch bandage is systematically applied from the fingertips to the double tourniquet to help empty the venous bed.
The technique consists of the following steps:
1. An IV cannula is inserted in the extremity opposite to the block side.
2. A double pneumatic tourniquet is placed on a padding layer of soft cloth (stockinette) with the proximal cuff high on the upper arm.
3. An IV cannula is inserted and carefully secured into a peripheral vein of the operative limb, as far distally as feasible. The cannula is flushed with saline before capping (Figure 3).
4. The entire arm is elevated for 1 to 2 minutes to allow for passive exsanguination (Figure 4). After exanguination, while still keeping the arm high, a rubber Esmarch bandage is wrapped around the arm, spirally from the hand to the distal cuff of the double tourniquet, to exsanguinate the extremity completely (Figure 5).
5. While the axillary artery is digitally occluded, the proximal cuff is inflated to 50 to 100 mm Hg above systolic arterial blood pressure (Figure 6).
6. Sequence for initial tourniquet management
a. Exsanguinate by elevation and Tourniquet wrapping
b. Inflate distal cuff
c. Inflate proximal cuff
d. Deflate distal cuff
Figure 6: With the Esmarch in place, the double tourniquet is inflated in the following sequence: The distal cuff (red) is inflated first, followed by inflation of the proximal cuff (blue). Once the proximal cuff is inflated and checked for functionality, the distal cuff is deflated. The cuff pressure is determined by the patient’s systolic blood pressure; the cuff pressure should be about 100 mmHg above the arterial systolic blood pressure.
7. Inject local anesthetic
8. After reaching the correct pressure, the Esmarch ban- dage is removed and 12 to 15 mL of preservative-free 2% lidocaine HCl (or 30-50 mL of 0.5% lidocaine HCl) is slowly injected via the indwelling extra catheter (20 mL/ min) (Figure 7). The volume depends on the size of the arm being anesthetized and the concentration of the anesthetic solution. Commonly recommended maximal dose is 3 mg/kg.
9. After the injection, the arm is lowered to the level of the table. The IV cannula from the anesthetized hand is removed, and in a sterile manner, pressure is quickly applied over the puncture site.
10. The onset of anesthesia is almost immediate after injection. When the tourniquet pain is reported by the patient, the distal cuff should be inflated and the proximal cuff deflated about 25 to 30 minutes after the beginning of anesthesia (Figure 8).
Choice of Local Anesthetic
Figure 7: With the extremity exsanguinated and the proximal cuff inflated, local anesthetic is injected to anesthetize the extremity.
Almost all local anesthetic agents have been reported to have been used for IVRA. At present, lidocaine remains the most commonly used local anesthetic of choice in North America. When used in the recommended dose of not more than 3 mg/kg, it appears to be remarkably safe in IV regional blockade. Most researchers report the use of a large volume of a dilute solution of local anesthetic. We often use a smaller volume of a concentrated agent to simplify by avoiding the need for dilution and multiple syringes. By using smaller volumes, we find the procedure tends to be more straightforward and less time consuming; the medication is simpler to prepare and easier to inject.
In some European institutions, prilocaine remains a preferred agent in IVRA. It may be the least toxic of the drugs used currently, and it is better tolerated than lidocaine in terms of systemic and central nervous system side effects. However, because it has been associated with the formation of methemoglobin, prilocaine is not used in North America.
Much research has been done on suitable adjuncts and additives to reduce anesthetic dose and to obtain improved tourniquet tolerance, better muscle relaxation, and prolonged postoperative pain control. Research evidence suggests that some adjuvants may offer some benefits. (e.g., ketorolac, clonidine, meperidine, and muscle relaxants). However, in our opinion, the marginal benefits may not justify the routine use of any additive because they do not outweigh the risk of increased complexity, potential for side effects, and drug error that may occur during addition of adjuvants to local anesthetics.
Block Dynamics and Perioperative Management
Figure 8: Management of the tourniquet pain. When the patient complains of tourniquet pain, the distal cuff (red) is inflated. Once the distal tourniquet is assured to be inflated and functional, the proximal tourniquet (blue) is deflated. All connectors must be clearly labeled (color coded in our practice) to avoid error in the sequence of inflation/deflation.
With a Bier block, anesthesia of the extremity typically develops within 5 minutes. Progressive numbness and complete insensitivity are followed by patchy decolorization of the skin and motor paralysis. Some patients report a tingly or cold sensation in the limb. However, with adequate premedication, this sign is often missed. After 30 to 45 minutes, the majority of patients report discomfort at the site of the inflated tourniquet. When this occurs, the distal cuff of the tourniquet should be inflated and the proximal cuff deflated. This maneuver provides immediate and significant relief, and the patient gains an additional 15 to 30 minutes of relative comfort. As soon as the patient gives notice of tourniquet pain, the surgeon should be consulted for information on the expected time necessary to complete the operation. The proximal tourniquet however, should never be released before inflation of the distal cuff. Proper labeling of the proximal and distal cuffs and their respective valves is of the utmost importance. Deflation of the wrong cuff will result in the rapid loss of anesthesia and the risk of systemic local anesthetic toxicity.
With respect to deflating the tourniquet at the end of a short surgical procedure (i.e.,
Untoward sequelae are few. Most of the reports of complications are related to equipment failure or other factors not directly attributable to the method itself (e.g., neglecting protocol guidelines). Table 1 lists complications and ways to prevent them.
Table 1: Complications and how to Avoid Them